Transexual Menace takes its title from the name of "the most exciting political action group in the USA"—transgendered people who are defining themselves, demanding their legal rights, and fighting for medical care and against job discrimination. Considered by von Praunheim to be the “most fascinating [project] in my long life as a filmmaker,” Transexual Menace is a sensitive and carefully crafted portrait that deals with issues openly and honestly. “I was able to earn the trust of many who are often reluctant to be interviewed. Courageous people talked to me, who transitioned in such problematic professions as law enforcement and firefighting.” Transexual Menace gives viewers remarkable insight into the home and work lives of transexuals from many cultures and countries, including female-to-male transexuals and those with families and children.